Comparison Between the Suture and the Macrosphere Model Using Magnetic Resonance Complications and Pitfalls in Rat Stroke Models for Middle Cerebral Artery
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Tibo Gerriets, Erwin Stolz, Maureen Walberer, Clemens Müller, Carina Rottger, Alexander Angiography Comparison Between the Suture and the Macrosphere Model Using Magnetic Resonance Complications and Pitfalls in Rat Stroke Models for Middle Cerebral Artery Occlusion : A Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2004 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/01.STR.0000142134.37512.a7 2004;35:2372-2377; originally published online September 2, 2004; Stroke. http://stroke.ahajournals.org/content/35/10/2372 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography.
BACKGROUND AND PURPOSE Investigating focal cerebral ischemia requires animal models that are relevant to human stroke. Complications and side effects are common among these models. The present study describes potential pitfalls in 3 techniques for middle cerebral artery occlusion (MCAO) in rats using magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA). METHODS Rats were ...
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BACKGROUND AND PURPOSE The suture middle cerebral artery occlusion (MCAO) model is widely used for the simulation of focal cerebral ischemia in rats. This technique causes hypothalamic injury resulting in hyperthermia, which can worsen outcome and obscure neuroprotective effects. Herein, we introduce a new MCAO model that avoids these disadvantages. METHODS Permanent MCAO was performed by int...
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Background & Aims: Ischemic postconditioning, conducted by a series of brief occlusion and release of the bilateral common carotid arteries, has neuroprotective properties in permanent or transient models of middle cerebral artery (MCA) occlusion but its delayed neuroprotective effects in the embolic model of stroke, especially in female rat, have not yet been reported and were investigated ...
متن کاملNeuroprotective effects of MK-801 in different rat stroke models for permanent middle cerebral artery occlusion: adverse effects of hypothalamic damage and strategies for its avoidance.
BACKGROUND AND PURPOSE Permanent middle cerebral artery occlusion (MCAO) with the use of the suture technique causes hypothalamic damage with subsequent hyperthermia, which can confound neuroprotective drug studies. In the present study the neuroprotective effects of dizocilpine (MK-801) were compared in different permanent MCAO models with and without hypothalamic damage and hyperthermia. ME...
متن کاملInvestigate the effect of TRPV1 receptor antagonist (AMG9810) on stroke outcome in the permanent middle cerebral artery occlusion in male rat
Introduction: TRPV1 is a non-selective cation channel with high permeability to calcium ions, and is also involved in the development of neurogenic and inflammatory pain. The increase in intracellular calcium plays a role in worsening of stroke. In the present study we investigated the effect of (AMG9810) TRPV1 receptor antagonist on stroke outcome in the permanent middle cerebral artery occlus...
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تاریخ انتشار 2004